Wed.May 31, 2023

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ASCO: Novartis pressures Lilly with Kisqali, targeting $3B opportunity in early breast cancer

Fierce Pharma

Adding Kisqali to endocrine therapy after surgery reduced the risk of invasive tumor recurrence or death by 25% in certain early-stage breast cancers.

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XtalPi announces $250m AI drug discovery collaboration with Eli Lilly

Pharmaceutical Technology

XtalPi has made a partnership deal with US-based Eli Lilly to leverage artificial intelligence (AI) for drug discovery. XtalPi will receive $250m in upfront and milestone payments. The two companies will use XtalPi’s integrated AI capabilities and robotics platform for the de novo [without consideration of previous instances] design and delivery of drug candidates for an undisclosed target.

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Trending Sources

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FDA warns patients about compounded versions of Novo Nordisk's Ozempic, Wegovy

Fierce Pharma

FDA warns patients about compounded versions of Novo Nordisk's Ozempic, Wegovy kdunleavy Wed, 05/31/2023 - 13:02

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Janssen submits NDA to FDA for PAH combination therapy

Pharmaceutical Technology

The Janssen Pharmaceutical Companies of Johnson & Johnson has submitted a new drug application (NDA) for its investigational single-tablet combination therapy of macitentan 10mg and tadalafil 40mg (M/T STCT) to the US Food and Drug Administration (FDA), to treat pulmonary arterial hypertension (PAH). The company is seeking approval for the combination therapy for the long-term treatment of PAH in adult patients with World Health Organisation functional class II-III.

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How to Stay Competitive in the Evolving State of Martech

Marketing technology is essential for B2B marketers to stay competitive in a rapidly changing digital landscape — and with 53% of marketers experiencing legacy technology issues and limitations, they’re researching innovations to expand and refine their technology stacks. To help practitioners keep up with the rapidly evolving martech landscape, this special report will discuss: How practitioners are integrating technologies and systems to encourage information-sharing between departments and pr

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Former Novartis execs cleared of Greek bribery charges after yearslong investigation

Fierce Pharma

After a yearslong investigation involving politicians and medical professionals alike, Novartis is looking to close the books on its Greek bribery imbroglio. | After an investigation that dates back to 2017, four former Novartis executives and a Greek politician were cleared of bribery charges. But 15 doctors were charged for their alleged involvement.

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Reframing Mental Health Awareness Month

InCrowd

Happy Mental Health Awareness Month! But wait… is it really happy? What does mental health awareness truly mean? I’ve always struggled with the idea of dedicating a single month to a specific cause. While it’s important to de-stigmatize mental illness and endeavor to provide mental health organizations with desperately needed funding, I worry that awareness will wane the moment this month ends?

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SNIPR targets antibiotic resistance with CRISPR-based gene therapy trial

Pharmaceutical Technology

The Danish CRISPR biotech SNIPR BIOME has released the first glimpse at the safety profile for SNIPR001, a gene therapy intended to target antibiotic resistance. Interim clinical results from a Phase I trial have demonstrated SNIPR001’s safety in healthy volunteers. Additionally, E.Coli was detected in a dose-dependent manner in feces, suggesting the therapy’s proof-of-principle targetin and removing the bacteria, including antibiotic-resistant strains.

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AbbVie's Rinvoq passes midstage test in systemic lupus erythematosus, heads into phase 3

Fierce Pharma

AbbVie's Rinvoq passes midstage test in systemic lupus erythematosus, heads into phase 3 esagonowsky Wed, 05/31/2023 - 09:39

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Stealth and Pharmanovia partner for commercialisation of elamipretide

Pharmaceutical Technology

Stealth BioTherapeutics has made an exclusive licensing agreement with Pharmanovia for the commercialisation of its elamipretide to treat Barth syndrome. Pharmanovia will hold exclusive rights for the commercialisation of elamipretide in the EU, other European countries including Switzerland, Norway, Iceland and the UK, and the Middle East and northern Africa region.

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NICE gives thumbs-up to Pfizer's migraine drug—but with lots of restrictions

Fierce Pharma

NICE gives thumbs-up to Pfizer's migraine drug—but with lots of restrictions kdunleavy Wed, 05/31/2023 - 09:43

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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ChatGPT in Healthcare – The Promise and the Danger

MedCity News

AI-generated information can be considered akin to obtaining a second or even third opinion regarding one’s health – it makes up part of what needs to be known, but it’s not the entire story.

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Big Pharma inventory management trends revealed

European Pharmaceutical Review

The inventory position of 28 major pharmaceutical manufacturers in 2022 has been revealed in an annual report. Analysis explored the impact of macro-trends on inventory management from corporate reports of Big Pharma companies including Merck, AstraZeneca and Pfizer. It investigated how excessive inventories are affecting the industry and what factors could influence inventory growth in 2023.

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Health Inequity Has Been Reduced to a ‘Checklist of Unmet Social Needs,’ Exec Says

MedCity News

Health equity strategies need to take factors like racism and lack of power into account, said Dr. Shreya Kangovi, executive director of the Penn Center for Community Health Workers. She made these comments last week at the MedCity INVEST conference in Chicago.

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CRISPR-based microbial gene therapy delivers promise

European Pharmaceutical Review

The novel CRISPR-Cas therapeutic selectively targets antibiotic-resistant E. coli which can cause life-threatening bloodstream infections” Positive interim results from a Phase I trial have demonstrated that the first CRISPR-armed phage microbial gene therapy can reduce Escherichia coli ( E. coli ) levels in the GI tract. “With the combined killing effects of bacteriophages and CRISPR-Cas technology, SNIPR001 has demonstrated the ability to target and eliminate antibiotic-resistant E

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ABM Evolution: How Top Marketers Are Using Account-Based Strategies

In times of economic uncertainty, account-based strategies are essential. According to several business analysts and practitioners, ABM is a necessity for creating more predictable revenue. Research shows that nearly three-quarters of marketers (74%) already have the resources needed to build successful ABM programs.

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Sanofi MS Drug Shines in Phase 2, Paving Way for a Pivotal Test Next Year

MedCity News

Frexalimab, a Sanofi drug candidate with roots at Dartmouth’s medical school, has met the main goal of its Phase 2 test. The encouraging data for this program come as different experimental Sanofi MS drug nears its one-year anniversary under FDA clinical hold.

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Woman of the Week: Mirati Therapeutics’ Laurie Stelzer

PharmaVoice

With the recent approval of Krazati, the biotech veteran is guiding Mirati into its next phase as a commercial-based organization.

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Strive Health Rakes In $166M for Value-based Kidney Care

MedCity News

Strive Health’s $166 million funding round was led by NEA and included participation from CVS Health Ventures, CapitalG, Echo Ventures, Town Hall Ventures, Ascension Ventures and Redpoint. In total, the company has raised more than $400 million.

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3 Ways Longevity Positively Impacts Medical Equipment Sales Careers

MedReps

When it comes to medical equipment sales careers, longevity is one thing that can make you more successful than your counterparts. Sure, you may feel the need to switch up your specialties or employers based on the ongoing trends in the field, but this may cause more detriments to your career. As it turns out, selling medical equipment and spending years both in the field and working for the same employer comes with many benefits, including these three. 1) You Know the Products Well Medical equi

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ABM Success Recipe: Mastering the Crawl, Walk, Run Approach

Shifting to an account-based marketing (ABM) strategy can be both exciting and challenging. Well-implemented ABM motions build engagement with high-value accounts and drive impactful campaigns that resonate with your audience. But where do you begin, and how do you progress from crawling to running? Watch now as Demand Gen experts delve into the essentials of each stage of the ABM process.

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Making Healthcare Access More Shoppable to Build Enduring Relationships with Patients [Sponsored]

MedCity News

A recent webinar sponsored by DexCare explored how the consumerization trend is shifting expectations for health consumers and how companies are enlisting AI tools such as machine learning and Chat GPT to improve the patient experience. Register to access the recording.

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Workflow of the Future: Sustainable Business Models

Copyright Clearance Center

The post Workflow of the Future: Sustainable Business Models appeared first on Copyright Clearance Center.

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Clinicians Offer Snapshot from Day in the Life of Delivering Care at Teladoc Health [Sponsored]

MedCity News

In a series of interviews, two Teladoc Health physicians and a therapist offered a window into a day in the life of delivering virtual care.

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Amgen’s Otezla shows promise in psoriatic arthritis

PharmaTimes

The inflammatory form of arthritis is estimated to affect nearly 38 million people worldwide

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How Intent Data Helps Marketers Convert A-List Accounts

One of the biggest challenges for any B2B marketer is understanding your prospects’ next move — who is most likely to buy and when. Without these insights, marketing campaigns can feel more like guesswork, with high investment and little return. We’re here to tell you there’s a better way. By tracking buyers’ digital footprints and online activity, such as website visits, product reviews, and spikes in content consumption, you can engage prospects with a message that really resonates.

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Healthcare Moves: A Monthly Summary of Hires and Layoffs

MedCity News

Here is a selection of recent executive hires, exits, promotions and layoffs occurring across the healthcare industry.

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University of Sydney will use AI to boost cancer drug research

Pharmaceutical Technology

The University of Sydney and Australian company Pharos Therapeutics have reached an agreement to leverage artificial intelligence (AI) to progress drug discoveries for the treatment of cancer and rare diseases. The university and Pharos have drawn up a memorandum of understanding (MoU) to use AI technology to identify potential compounds for the rapid development of treatments.

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Roller Compaction: New Trends, Challenges and Solutions

PharmaTech

When developing a tablet or capsule formulation, three widely used technologies are often considered to produce solid dosage forms: direct compression, wet granulation and dry granulation (including roller compaction). This article discusses why roller compaction is a robust option.

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Demystifying the 5G standard essential patent landscape: Phase 4

Clarivate

A new report [1] from Clarivate patent experts provides an update on 5G standards-essential patent declarations. In our Demystifying the 5G standard essential patent landscape : Phase 3 report published in March 2022, we presented the statistics of patents declared as essential to 5G standards as of December 31, 2021. We present statistics in a new report that captures new declarations, new 5G standards, new patent applications and new grants within the patent families.

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Solving the Biggest Tech Challenges in RevOps

In this eBook, we’ll run through real-world examples that show how RevOps teams can benefit from modern solutions for the access, management, and activation of their GTM data. Whether you need to improve lead response times, boost adoption of core tools, improve lead qualification, or target and automate your GTM motions, you’ll find examples of how revenue teams are solving some of the toughest problems in modern business.

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Direct Compression of Probiotics with PROSOLV® EASTtab Nutra

PharmaTech

Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of production effort, cost efficiency and stability of the probiotic bacteria.

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ZNA-1041 by F. Hoffmann-La Roche for Solid Tumor: Likelihood of Approval

Pharmaceutical Technology

ZNA-1041 is under clinical development by F. Hoffmann-La Roche and currently in Phase I for Solid Tumor. According to GlobalData, Phase I drugs for Solid Tumor have a 54% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how ZNA-1041’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks.

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Nexcella Begins Production of CAR-T Cell Therapy Engineering Batches at US Manufacturing Site

PharmaTech

The start of production of US engineering batches of NXC-201, a CAR-T cell therapy candidate in early clinical development, is the first step in transferring Nexcella’s existing manufacturing process to the United States.

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ISPOR 2023: A Focus on Quality

Prognos Health

Todd Somsel , Commercial Lead, RWD Marketplace The acceptance and application of real-world evidence (RWE) by stakeholders across the healthcare industry continues its rapid pace of growth. And as these stakeholders are presented with more and more RWE from pharmaceutical manufacturers, they are asking tough questions to better understand whether to use this evidence when making critical decisions that impact the health of patients.

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Drive GTM Efficiency with Tech Stack Consolidation

Consolidating your tech stack is an effective cost-saving measure that drives GTM efficiency and adds value to your enterprise. With a cohesive, integrated tech stack, your revenue teams can deliver an excellent customer experience that sets you up to win faster than your competitors.