pharmaphorum

DECEMBER 20, 2022

The condition is largely associated with obesity and an unhealthy diet and lifestyle, and is on the rise in industrialised nations, leading to estimates it could present a market opportunity worth tens of billions of dollars worldwide.

Pharmacology 52

Pharmacology Pharma Marketing Biopharma 52

European Pharmaceutical Review

MARCH 11, 2024

Self-stigma is also prevalent and hinders individuals from getting tested, starting pre‑exposure prophylaxis (PrEP) (if they’re HIV negative), seeking the lifesaving treatments they need (if they’re HIV positive), and can lead to isolation and depression.

Medicine 92

Medicine Pharmacology Healthcare Healthcare 92

Legacy MEDSearch

AUGUST 25, 2022

The primary safety endpoint is a performance goal for device and procedure related adverse events at 30 days. The FDA-approved randomized IDE trial has been designed to validate the safety and effectiveness of PiCSO.” Major adverse cardiac events and heart failure endpoints will be captured acutely and for up to 3 years.

Medical 52

Medical FDA Recruitment Pharmacology 52

European Pharmaceutical Review

MAY 2, 2023

Cancer remains a global threat with around 10 million people dying from the disease each year worldwide, making it the second leading cause of death. By collaborating with several stakeholders and authorities, multiple stages of development can take place concurrently to speed up R&D without compromising safety protocols.

Patients 101

Patients Medicine Marketing Medical 101

European Pharmaceutical Review

JULY 27, 2023

Cardiovascular diseases are the leading cause of death globally with over 18.5 Cardiovascular diseases are the leading cause of death globally with over 18.5 Despite these trials varying in design, they confirmed the feasibility and safety of the procedure. 1 Furthermore, there are 63.3 1 Furthermore, there are 63.3

Pharmacology 93

Pharmacology Manufacturing Leads Medicine 93

European Pharmaceutical Review

SEPTEMBER 22, 2023

Targeting toxic species of Abeta, such as multimers (with aducanumab and lecanemab) or pyroglutamate Abeta3-42 (with donanemab), induced significant removal of Abeta plaque load in the brains of Alzheimer’s patients, leading to the delay in cognitive decline. Treatment with the mAbs delayed cognitive decline by 2.6 months for lecanemab and 5.5

Food and Drug Administration 79

Food and Drug Administration Safety Patients Leads 79

European Pharmaceutical Review

DECEMBER 11, 2023

mAbs have well-established safety profiles, high specificity and affinity and long half-lives – they have been used in drug development for more than 30 years. Known linkers in the RNA field are used to bond together the two pharmacologically active molecular entities and can be applied to multiple oligonucleotide modalities.

Pharmacology 85

Pharmacology Safety Engineering Medical 85

Pharmaceutical Technology

FEBRUARY 8, 2023

Blank acknowledged that in many cases, an exclusively paediatric patient population could lead to difficulties with drawing consent for early phase trials. Still, Blank suggested that companies enroll the patient population that is most likely to benefit, because early phase studies contain the most safety risks.

FDA 105

FDA Pharmacology Patients Pharmaceutical 105

Pharmaceutical Technology

FEBRUARY 13, 2023

Key considerations in the candidate selection stage The first step in a drug development program is choosing the optimum molecule from a range of potential leads that have been optimized within drug discovery. We start by using in-silico modeling of any pre-existing data associated with the lead compounds.

Food and Drug Administration 52

Food and Drug Administration Leads Pharmaceutical Pharmaceutical research 52

Quantified

JUNE 28, 2022

The reality is that leading companies are looking for ways to drive impact that go beyond optimizing reach and frequency. To do this, they will not only need new knowledge but a substantially better ability to engage, connect and influence the HCP, leading to more meaningful interactions and increased conversion.

Sales 52

Sales Pharma Training Management 52

Pharmaceutical Technology

AUGUST 8, 2022

These days, he is leading trials involving a system developed by the digital health company etectRx (pronounced as e-tect-are-ex), which works with investigators who can use such real-time data. But the pharmacology to quantify adherence also depends on race, gender, weight, and other factors.

Food and Drug Administration 122

Food and Drug Administration FDA Medicine Patients 122

Pharmaceutical Technology

FEBRUARY 17, 2023

In January, amidst calls to improve patient safety by optimizing licensed drug formulations, the FDA released a draft guidance that signalled a departure from the most commonly used method of identifying a new therapy’s ideal dosage. The clinical pharmacology knowledge also isn’t present at smaller companies, he adds.

FDA 115

FDA Side effects Pharmacology Patients 115