European Pharmaceutical Review

MARCH 11, 2024

Self-stigma is also prevalent and hinders individuals from getting tested, starting pre‑exposure prophylaxis (PrEP) (if they’re HIV negative), seeking the lifesaving treatments they need (if they’re HIV positive), and can lead to isolation and depression. 3 But that paradigm is rapidly changing.

Medicine 91

Medicine Pharmacology Healthcare Healthcare 91

European Pharmaceutical Review

JULY 27, 2023

Cardiovascular diseases are the leading cause of death globally with over 18.5 Cardiovascular diseases are the leading cause of death globally with over 18.5 Despite these trials varying in design, they confirmed the feasibility and safety of the procedure. 1 Furthermore, there are 63.3 1 Furthermore, there are 63.3

Pharmacology 92

Pharmacology Manufacturing Leads Patients 92

European Pharmaceutical Review

SEPTEMBER 22, 2023

Targeting toxic species of Abeta, such as multimers (with aducanumab and lecanemab) or pyroglutamate Abeta3-42 (with donanemab), induced significant removal of Abeta plaque load in the brains of Alzheimer’s patients, leading to the delay in cognitive decline. Treatment with the mAbs delayed cognitive decline by 2.6 percent and 14.3

Food and Drug Administration 78

Food and Drug Administration Safety Patients Leads 78

Pharmaceutical Technology

FEBRUARY 8, 2023

On February 7, at a town hall organised to discuss clinical trial designs for gene therapies, FDA experts pushed pharma players to look for ways to establish clinical effectiveness despite the challenges in recruiting patients with rare diseases.

FDA 105

FDA Pharmacology Patients Pharmaceutical 105

European Pharmaceutical Review

DECEMBER 11, 2023

The first approved ASO was designed for injection directly into the eye for the local treatment of cytomegalovirus (CMV) retinitis in immunocompromised AIDS patients. mAbs have well-established safety profiles, high specificity and affinity and long half-lives – they have been used in drug development for more than 30 years.

Pharmacology 85

Pharmacology Safety Engineering Medical 85

Pharmaceutical Technology

FEBRUARY 13, 2023

Key considerations in the candidate selection stage The first step in a drug development program is choosing the optimum molecule from a range of potential leads that have been optimized within drug discovery. We start by using in-silico modeling of any pre-existing data associated with the lead compounds.

Food and Drug Administration 52

Food and Drug Administration Leads Pharmaceutical Pharmaceutical research 52

Pharmaceutical Technology

AUGUST 8, 2022

Proteus Health’s Abilify MyCite had an ingestible sensor that could track if a patient consumed the drug. You don’t want to use this to stigmatize patients or to ‘catch them lying.’ A patient probably does not know what they’re signing, but still do it in order to access whatever treatment they need, she adds.

Food and Drug Administration 122

Food and Drug Administration FDA Medicine Patients 122

Quantified

JUNE 28, 2022

On the one hand, patient need for access and business need to restore and accelerate sales and prescription momentum have never been more critical. The reality is that leading companies are looking for ways to drive impact that go beyond optimizing reach and frequency. Step 2: Audit Marketing & Sales Alignment.

Sales 52

Sales Pharma Training Management 52

Pharmaceutical Technology

FEBRUARY 17, 2023

In January, amidst calls to improve patient safety by optimizing licensed drug formulations, the FDA released a draft guidance that signalled a departure from the most commonly used method of identifying a new therapy’s ideal dosage. For this approach, a “3+3” model is used where a study enrolls three patients into a given dose cohort.

FDA 115

FDA Side effects Pharmacology Patients 115