Remove tag novel-targeted-cancer-treatments
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After a slow start for expensive CAR-T therapies, drug developers revisit oral therapies for blood cancer

pharmaphorum

There’s been huge progress in treatments for blood cancer in recent years – but drawbacks of expensive CAR-T cell and injected antibody therapies have led drug developers to look at novel oral therapies as patient-friendly alternatives.

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Actualising the power of antibody-drug conjugates as cancer therapeutics

European Pharmaceutical Review

ANTIBODY-DRUG conjugates (ADCs) are therapeutic molecules designed as highly targeted medicines with the promise of changing the way we treat cancer and other diseases. cancer agent or disease-relevant toxin. 1 While the first successes underscored the potential of this class of targeted therapies, they also revealed bottle?

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A broad range of unmet needs remains in the immuno-oncology space

Pharmaceutical Technology

Immuno-oncology (IO) agents have transformed the cancer therapeutics landscape, driving long-term remissions in a subset of patients who historically had limited options. All currently approved CAR-Ts are autologous, with the patient’s T-cells being genetically engineered to target antigens expressed by the cancerous cells.

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Putting complex medicines under the microscope

European Pharmaceutical Review

The biological characterisation of complex medicines is fundamental to translate these novel therapeutics and associated drug delivery technologies into the clinic; to understand the interplay with biological systems and to evaluate new formulations?. Modifying or developing targeting moieties is necessary to improve extrahepatic delivery.

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Developing point-of-care CAR T manufacturing

European Pharmaceutical Review

Product distribution requires shipping of apheresis starter materials, either cryopreserved or fresh (depending on the product), to the manufacturing site as well as shipping of final cryopreserved products to treatment centres. This is in addition to its considerable price tag. 6-8 Clinical recommendations also change.