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Leading innovators in peptide-based inhibitors for cancer treatment

Pharmaceutical Technology

As molecular targeting peptides, anti-cancer peptides penetrate the plasma membrane, nuclear membrane, and mitochondrial membrane of cancer cells, exerting pharmacological activity through various mechanisms (such as inhibiting DNA synthesis and cell division), thus causing apoptosis of cancer cells.

Leads 52
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Leading innovators in tetrapeptide derivatives for the pharmaceutical industry

Pharmaceutical Technology

Several tetrapeptides are pharmacologically active, showing affinity and specificity for multiple receptors in protein-protein signalling. Whilst Abliva and Ambrx Biopharma stand in second and third positions, respectively. Merck 42 Unlock company profile C. Menarini Industrie Farmaceutiche Riunite.

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Leading innovators in pyridine derivatives for the pharmaceutical industry

Pharmaceutical Technology

Pyridine derivatives contain one nitrogen atom in a six-membered aromatic ring and are the most extensively used heterocycles in the field of drug design, due to their promising effect on pharmacological activity, which has led to the discovery of numerous broad-spectrum therapeutic agents.

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Madrigal sees road to approval for NASH drug resmetirom

pharmaphorum

The condition is largely associated with obesity and an unhealthy diet and lifestyle, and is on the rise in industrialised nations, leading to estimates it could present a market opportunity worth tens of billions of dollars worldwide.

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Understanding a rare disease through the lens of real world and prevalence data

Clarivate

Degeneration of the retinal ganglion cells causes rapidly progressing vision loss, leading to permanent (non-painful) blindness within a year. Frontiers in Pharmacology; 13:1089033; DOI: 10.3389/fphar.2022.1089033 Learn more about the Clarivate real world data offering here. References [1] Sundaramurthy S et al. ” Cureus; V.12;