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Leading innovators in peptide-based inhibitors for cancer treatment

Pharmaceutical Technology

As molecular targeting peptides, anti-cancer peptides penetrate the plasma membrane, nuclear membrane, and mitochondrial membrane of cancer cells, exerting pharmacological activity through various mechanisms (such as inhibiting DNA synthesis and cell division), thus causing apoptosis of cancer cells.

Leads 52
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Leading innovators in tetrapeptide derivatives for the pharmaceutical industry

Pharmaceutical Technology

Several tetrapeptides are pharmacologically active, showing affinity and specificity for multiple receptors in protein-protein signalling. In nature, tetrapeptides (CTPs) are both linear and cyclic, with the latter mimicking reverse turns commonly found on the surfaces of proteins and targets for drug therapy.

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Madrigal sees road to approval for NASH drug resmetirom

pharmaphorum

The road to the development of treatments for non-alcoholic steatohepatitis (NASH) is littered with failed projects, but US biotech Madrigal Pharma thinks it now has enough evidence for its drug resmetirom to support regulatory filings. Although, so far efforts to bring a therapy to market have failed.

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Understanding a rare disease through the lens of real world and prevalence data

Clarivate

Degeneration of the retinal ganglion cells causes rapidly progressing vision loss, leading to permanent (non-painful) blindness within a year. Frontiers in Pharmacology; 13:1089033; DOI: 10.3389/fphar.2022.1089033 Learn more about the Clarivate real world data offering here. References [1] Sundaramurthy S et al. ” Cureus; V.12;