Remove tag her2
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Actualising the power of antibody-drug conjugates as cancer therapeutics

European Pharmaceutical Review

A striking example is the human epidermal growth factor receptor 2 (HER2) space, 4 where Kadcyla (ado?trastuzumab tag ® , inspired by the unique features of microtubule biology and perfectly suited for DAR 2 and DAR 4 ADCs. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer. Chemical Science.

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Putting complex medicines under the microscope

European Pharmaceutical Review

BT-474 cell line was gene-edited to incorporate a green fluorescent protein (GFP) tag into late endosomes/lysosomes (green). Treatment with HER2 Trastuzumab (red) results in uptake and trafficking into endosomes (white arrows indicate co-localisation). Physical characterisation.

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