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Handling HPAPIs safely – what does it take?

European Pharmaceutical Review

1 These substances “are pharmacologically and biologically active at low doses,” Dr Kishore Hotha, Global Head of Analytical Research & Development at Veranova, explained. ” Highly potent APIs are pharmacologically and biologically active compounds at low doses. What training is required for employees to handle HPAPIs safely?

Safety 89
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Toolbox to Study Ligand Binding for Enhanced Treatments

Medgadget

The basis for many pharmacological interactions between drugs and cells, and indeed many physiological or pathological interactions involving biological signaling molecules, involves a molecule, termed a ligand, binding to a receptor that is typically present on the cell membrane.

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Angion stock falls after agreeing Elicio Therapeutics merger

pharmaphorum

The AMP technology was developed by the laboratories of Darrell Irvine, professor of biomedical engineering in the Koch Institute of Integrative Cancer Research at MIT, who is a co-founder of Elicio, as well as serving as a consultant to the company and head of its scientific advisory board. . Darrell Irvine.

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Navigating the unique CMC challenges of oral anaerobic live biotherapeutics

European Pharmaceutical Review

Firstly, the pharmacological response to LBPs does not follow traditional pharmacokinetic principles. While engineering solutions can be implemented to ensure such conditions are applied for unit operations; these are not the usual considerations when manufacturing oral solid dose products.

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What Is OEM Sales? With Sean Pitts

Evolve Your Success

We would typically engage with Stryker’s engineering, product management, product development, marketing, or even their R&D teams. A re they engineers ? One is an engineer who came into sales. I was using all I knew about biology, physiology, and pharmacology. H ow does that work? They decide to create a device.

Sales 64
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Aevitas to sell sCFH asset rights to 4D Molecular

Pharmaceutical Technology

sCFH is an engineered and improved version of complement factor H (CFH) that can fit into adeno-associated virus (AAV) vectors with solid expression and applications confirmed in cultured human cells in vitro, in addition to various preclinical animal models in vivo. The firm will also receive single-digit royalties on net sales.

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Advancing AOCs to transform the delivery of RNA therapeutics

European Pharmaceutical Review

Based on learnings from ASOs and siRNAs they also leverage unique engineering and drug delivery techniques that enable them to target a broader set of cell types, including many that have been previously untreatable with RNA therapeutics. Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging.