Sat.Jun 03, 2023

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ASCO: Seagen's top-selling drug under threat as Bristol Myers' Opdivo beats Adcetris in lymphoma

Fierce Pharma

The rising antibody-drug conjugate class has hit a setback as Seagen’s Adcetris, one of the earliest and fast-growing members of the group, was defeated by immune checkpoint inhibitor. | The rising antibody-drug conjugate class has hit a setback as Seagen’s Adcetris, one of the earliest and fast-growing members of the group, was defeated by immune checkpoint inhibitor in classical Hodgkin lymphoma.

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Analysis of Gut Microbiome Did Not Show Significant Differences Relating to Immune Checkpoint Inhibition Resistance

Pharmacy Times

Fecal microbiota transplant from responders to non-responders was able to rescue immune checkpoint inhibition use in patients with melanoma, with 40% of patients showing clinical benefit.

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ASCO: J&J, Legend's Carvykti stages stellar show in earlier myeloma. But has the CAR-T reached a ceiling?

Fierce Pharma

After a recent data leak reveale | After a recent data leak revealed a dramatic benefit for J&J and Legend’s Carvykti in earlier treatment of multiple myeloma, the pair has peeled back some even more stunning efficacy results that could further pressure Bristol Myers Squibb’s rival CAR-T therapy, Abecma.

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New Manufacturing Process Could Improve CAR T Cell Efficacy Against Aggressive Form of Leukemia

Pharmacy Times

Expert said that manufacturing the T cells with a tyrosine kinase inhibitor may allow more patients to get allogeneic stem cell transplant, the current best means of long-term cure.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Tumor Fraction Retains Strong Prognostic Value for Advanced Non-small Cell Lung Cancer

Pharmacy Times

High tumor fraction after induction chemotherapy identifies a population with an unmet need who has low chances to benefit from immune checkpoint blockades.

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Expert: Genomic Testing Can Help Oncologists Customize Treatment Based on the Tumor Type

Pharmacy Times

Identifying alterations in tumor genes has enabled medical oncologists to guide patients towards more specific therapies.

Medical 29