The pharmaceutical industry continues to be a hotbed of innovation. Activity is driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Artificial Intelligence in Pharmaceuticals: In-silico drug discovery. Buy the report here.
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According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry.
In-silico drug discovery is a key innovation area in artificial Intelligence
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Drug research starts with the discovery stage that involves in vivo and in vitro models to shortlist lead drug compounds. Technology advances helped the pharmaceutical industry in many ways, especially the drug discovery process using computers. In-Silico or ‘computational’ methods include databases, quantitative SAR (structure-activity relationship), homology, and molecular modelling (docking). In silico methods generate lead compounds in less time with high accuracy and reduced cost.
GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 30+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of in-silico drug discovery.
Key players in in-silico drug discovery– a disruptive innovation in the pharmaceutical industry
‘Application diversity’ measures the number of different applications identified for each relevant patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.
‘Geographic reach’ refers to the number of different countries each relevant patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.
Patent volumes related to in-silico drug discovery
| Company | Total patents (2010 - 2022) | Premium intelligence on the world's largest companies |
| Codexis | 82 | Unlock Company Profile |
| Memorial Sloan Kettering Cancer Center | 61 | Unlock Company Profile |
| Adimab | 44 | Unlock Company Profile |
| Xencor | 41 | Unlock Company Profile |
| NantWorks | 31 | Unlock Company Profile |
| F. Hoffmann-La Roche | 24 | Unlock Company Profile |
| Glycosyn | 23 | Unlock Company Profile |
| ProvIncial Health Services Authority | 17 | Unlock Company Profile |
| Immatics | 16 | Unlock Company Profile |
| Mars | 14 | Unlock Company Profile |
| Nant Holdings Ip | 13 | Unlock Company Profile |
| PYC Therapeutics | 12 | Unlock Company Profile |
| Stem Cell Medicine | 12 | Unlock Company Profile |
| Enzo Biochem | 10 | Unlock Company Profile |
| ConfometRx | 10 | Unlock Company Profile |
| Laboratory of America Holdings | 9 | Unlock Company Profile |
| HealthTell | 9 | Unlock Company Profile |
| Sanofi | 9 | Unlock Company Profile |
| Immunexpress | 9 | Unlock Company Profile |
| Amorepacific Group | 7 | Unlock Company Profile |
| Ipsen | 7 | Unlock Company Profile |
| Ramot | 7 | Unlock Company Profile |
| Kflp Biotech | 7 | Unlock Company Profile |
| Biora Therapeutics | 6 | Unlock Company Profile |
| Sinoveda Canada | 6 | Unlock Company Profile |
| Children's Hospital of Philadelphia | 6 | Unlock Company Profile |
| The Henry M Jackson Foundation for the Advancement of Military Medicine | 6 | Unlock Company Profile |
| City of Hope | 5 | Unlock Company Profile |
| Vascular BioSciences | 5 | Unlock Company Profile |
| Honda Motor | 5 | Unlock Company Profile |
| Region Midtjylland | 5 | Unlock Company Profile |
| i2 Pharmaceuticals | 5 | Unlock Company Profile |
| Genesis Drug Discovery & Development | 5 | Unlock Company Profile |
Source: GlobalData Patent Analytics
Codexis, a protein engineering company, is the leading patent filer. It has 15 drug molecules in pipeline development for various indications including lysosomal storage disease, haemophilia A, Fabry disease, inflammatory bowel diseases, celiac disease, Pompe disease, and Phenylketonuria. Adimab and Xencor are the other key patent filers of in-silico drug discovery.
In terms of application diversity, HealthTell is the top company, followed by Xencor and Vascular BioSciences. By means of geographic reach, Mars held the top position. Amorepacific Group and Nant Holdings IP stood in the second and third positions, respectively.
To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Artificial Intelligence (AI) in Healthcare – Thematic Research.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
