Wed.Oct 05, 2022

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Biotech IPO market slowdown continues as third quarter is weakest since 2011

MedCity News

Third Harmonic Bio’s stock market debut was the only biotech IPO that crossed the $100 million threshold in the third quarter as the slowdown in IPO activity showed little sign of changing. Small deals continue to represent most of the IPO activity.

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High risk, high reward – the future of CAR-T therapy in CLL

Pharmaceutical Technology

In 2010, two patients with end-stage refractory chronic lymphocytic leukaemia (CLL) were administered Novartis’ autologous anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy, Kymriah (tisagenlecleucel), as part of a Phase I trial. In March this year, it was reported that these two patients were still in remission, making this the longest known CLL remission after CAR-T therapy and demonstrating to the industry that long-term remission is indeed possible.

Safety 111
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What Alignment Healthcare is doing in preparation for Medicare open enrollment

MedCity News

The insurer is expanding its offerings for its $0-premium Preferred Provider Organization plans and special needs plans for dually eligible beneficiaries. Alignment is adding 14 counties to its footprint, bringing its reach to 8.3 million Medicare-eligible adults in 52 markets.

Insurance 122
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Conductive Cotton Thread for Wearable Sensors in Commercial Textiles

Medgadget

Imperial College London researchers created a conductive cotton thread that can undergo a computerized embroidery process for incorporation into commercially produced textiles, such as t-shirts and face masks. The thread, called PECOTEX, can be used to create wearable health sensors, such as heart rate monitors, breathing monitors and even gas sensors, including ammonia sensors for the breath, which can provide information on liver and kidney function.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Elizabeth Holmes granted evidentiary hearing for new trial based on possible government misconduct

MedCity News

After a key witness arrived at Holmes’ house in August and expressed regrets about his role in the trial, a California judge has decided to grant Holmes a chance for a new trial.

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Online Learning Portal on the Impetus InSite Platform®: A Customer Story

Impetus Digital

In this customer story, we share how our client leveraged Impetus Digital’s large portfolio of life science-specific online collaboration tools and White-Glove services to: Conduct a needs assessment among embryologists and fertility specialists. Establish a small steering committee to co-create online course content related to updates in embryology and fertility medicine.

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Robotic Capsule Drills Intestinal Mucus to Deliver Protein Drugs

Medgadget

Engineers at MIT have collaborated to develop a robotic drug delivery capsule that is specially designed to administer delicate protein drugs, such as insulin, through the wall of the intestine. Proteins are not suited for oral delivery, as they are typically destroyed by the low pH in the intestine and they can’t pass through the mucus layer that lines the gastrointestinal tract.

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Consumers worried about healthcare costs as open enrollment nears, survey shows

MedCity News

In a survey of Americans with employer-sponsored coverage, 91% of respondents said they’ve experienced a payment-related issue in the past. Another 86% saying they’re worried their health benefits won’t cover all their healthcare needs.

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Sanofi wagers $400m on miRecule muscular dystrophy therapy

pharmaphorum

Sanofi has added to its rare disease pipeline by licensing an antibody-RNA conjugate (ARC) for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder, from US biotech miRecule. FSHD is the second most common form of muscular dystrophy after the Duchenne type, and affects around 1 million people worldwide, with no approved treatments.

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CommonSpirit takes IT systems offline amid cybersecurity incident

MedCity News

“An IT security issue” has been impacting several of CommonSpirit Health’s facilities across the country. Some of its hospitals in Nebraska, Iowa and Washington have taken their EHRs offline due to the incident. Experts say the incident serves as an important reminder that providers need to go all in on cybersecurity, as healthcare organizations remain a prime target for hackers.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Frontiers Health Steering Committee spotlight: Roberto Ascione

pharmaphorum

As we close in on Frontiers Health 2022, pharmaphorum is chatting with members of the Steering Committee to give you a sneak peek of what to expect in Milan. Interested in signing up? pharmaphorum readers get a discount through this link. As digital therapeutics come into their own, they’ve become a necessary force to be reckoned with for pharma, payers, and providers – as well as for the patients that will use them and the tech companies that make them.

Doctors 90
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Why Texas wants to be the headquarters of ARPA-H

MedCity News

Texas has the right environment to help ARPA-H achieve its promise of eliminating existing deficiencies in our national biomedical ecosystem, promoting the integration of multiple disciplines and institutions, and fully addressing persistent inequities in America’s health system.

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Collaborations between pharma and academia increase

European Pharmaceutical Review

The Association of the British Pharmaceutical Industry (ABPI)’s survey identified that the sector is helping industry entrants by embracing hands-on training methods such as apprenticeships, degree placements, PhDs and post-doctoral researcher awards, with data showing that apprentices being trained by pharmaceutical companies is the highest on record.

Pharma 87
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Scale Down Before Scaling Up: Digital Innovation in a Highly Regulated Industry

PharmExec

The highly-regulated pharmaceutical industry poses serious challenges that can derail digital health programs. But, there are solutions.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Digital health financing drops again, but don’t worry yet

pharmaphorum

After a bumper 2021, the fall-off in digital health financing deals that started to appear early this year has continued, with the three month to send September the lowest funded quarter since the tail end of 2019. All told, digital health companies raised $2.2 billion from 125 deals in the third quarter, taking the tally for 2022 to $12.6 billion and 458 deals, respectively, according to new figures from Rock Health which point to a big pullback in late-stage deal financing.

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Video Agility: Professionalism

Storyvine

One of the key attributes of Video Agility is professionalism. You want to increase the speed and scale of video production but you don’t want to look sloppy. What does it mean to create professional-quality video in a video agile environment? [link] The Attributes of Professionalism: On Brand/Message. The video should follow your brand standards and include your logo and brand colors.

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Effective People Leading and Motivating Sales Teams with Bryant Davis at SC Johnson

Map My Customers

Sales is hard work. And it’s not getting any easier. These days the majority of sales reps don’t meet their sales goals. It’s up to management to motivate them. Like SC Johnson’s Bryant Davis shared on the latest Field Sales Guide podcast from Map My Customers, “As you start thinking about a frontline sales team, they’ve got a million things coming at them.

Sales 70
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ALTURiX Acquires UK rights to desmopressin oral solution

PharmaTimes

Deal is part of mission to increase options available prescribers, patients and the NHS

Patients 104
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Biogen’s $900 million settlement signals scrutiny on speaker fees

Pharmaceutical Technology

Bringing an end to a 13-year deliberation on a whistleblower lawsuit, Biogen recently agreed to pay a $900 million settlement , amidst increased government alertness on pharmaceutical fraud. In 2009, former Biogen employee Michael Bawduniak filed a lawsuit claiming that Biogen had violated the False Claims Act and the Anti-Kickback Statute by providing millions of dollars to healthcare providers (HCPs) as an incentive to prescribe three of its multiple sclerosis (MS) drugs.

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GSK’s Jemperli/TIM-3 immuno-oncology combo moves to ph3

pharmaphorum

GSK’s latecomer to the PD-1/PD-L1 inhibitor category Jemperli has barely started to bring in revenues, and is a world away from the company’s hopes of blockbuster revenues by 2031. The drugmaker remains convinced of the potential of the drug, however, and has just reported results of trial comparing Jemperli (dostarlimab) to Merck & Co’s market-leading Keytruda (pembrolizumab) showing it is as effective as its rival.

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Scientists awarded £1m to help women make childbirth choices

PharmaTimes

Group will develop an aid that can be used to guide discussion between pregnant women

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Expanding Your Network

Rep-Lite

Creating collaborative networks should be a top priority for all pharmaceutical companies. Because of the interconnectedness inside a network, you can accomplish shared goals more cheaply than if you attempted them separately. Search for knowledge, and its transfer are both made easier. It is essential to consider and incorporate the innovative power of specialist organizations and start-ups at all phases, from research and development to marketing and sales.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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FlyPharma Conference Europe 2022 shares the latest supply chain challenges and advice for better industry collaboration

PharmaTimes

On 20-21 September 2022, the FlyPharma Conference Europe made a welcome return as a live, in-person event

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Expanding Your Network

Rep-Lite

Creating collaborative networks should be a top priority for all pharmaceutical companies. Because of the interconnectedness inside a network, you can accomplish shared goals more cheaply than if you attempted them separately. Search for knowledge, and its transfer are both made easier. It is essential to consider and incorporate the innovative power of specialist organizations and start-ups at all phases, from research and development to marketing and sales.

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IP management: There’s significant value in getting it right

Clarivate

Can the way in which intellectual property (IP) assets are managed have a direct impact on your organization’s bottom line? While the costs of poorly managing those assets are generally understood – missed renewal deadlines, the lapse of an IP right and ultimate loss of revenue and/or the right – the value of getting IP management right is often overlooked.

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Global Incentive Compensation Trends in Life Sciences

PharmExec

Thursday, October 6, 2022 12 PM BST |1 PM CEST (Europe) Thursday, October 6, 2022 11 AM EDT | 8 AM PDT (US/CAN) Join IQVIA’s webinar exploring our first ever Global Incentive Compensation Benchmark Study including comprehensive feedback from a diverse group of IC professionals in the life sciences industry. Gain valuable information to maximize IC planning and execution that will equip field forces for current and future go-to-market success.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Mobilizing Agitation Detection in Children with ADHD

Impetus Digital

Marius Rus , founder of StressLess –the startup behind Tully , sat down with me for a discussion around wearable technologies for children with ADHD, autism, and other mental health conditions. He also shared his tips and lessons learned from founding two startups, plus much more. Here is a sneak peek of our conversation: Q: You started a company called StressLess and developed a wearable called Tully.

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Worldwide healthtech growth: how the UK and Scotland are positioned

Pharmaceutical Technology

Technology is advancing the possibilities of healthcare treatments, from the development of innovative new drugs to freeing up time for doctors thanks to monitoring devices for patients with conditions such as diabetes and high blood pressure. As health services around the world seek to recover from Covid-19, many are turning to healthtech to expand treatment options and increase efficiencies.

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Fireside Chat with Anthony Capone, President & CTO of DocGo

Impetus Digital

Register for Impetus’ upcoming live webinar on October 18, 11 AM – 12 PM ET: A Fireside Chat with Anthony Capone, President & CTO of DocGo. About the webinar. In this live episode of Healthcare Goes Digital, Anthony Capone , President & CTO of DocGo , sits down with Natalie Yeadon , Co-founder & CEO of Impetus Digital , to share how his company uses last-mile mobile health services and integrated medical transportation solutions to make healthcare more accessible for everyone,

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11 Market Access Questions to Address Prior to Launching Your First Specialty Drug

Pharmaceutical Commerce

Wednesday, October 5, 2022, 11am EDT Market access considerations can be complex to navigate and overwhelming to address for biopharmaceutical commercial teams launching their first specialty drug. Get answers to eleven key questions that will help guide commercial teams in effectively launching specialty products.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.