Mon.Aug 22, 2022

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Half of cancer deaths are preventable

World of DTC Marketing

Globally, nearly half of deaths due to cancer can be attributable to preventable risk factors, including three leading risks of smoking, drinking too much alcohol, or having a high body mass index, a new paper suggests. According to the Lancet “, although some cancer cases are not preventable, governments can work on a population level to support an environment that minimises exposure to known cancer risk factors.

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Magnetic Microrobots Assist with Root Canal Treatment

Medgadget

Researchers at the University of Pennsylvania have developed a microrobot system that can help with biofilm disruption, drug delivery, and sample retrieval, all within the restrictive space of the root canal. It can be difficult for dentists to know if they have removed all the infectious material when performing a root canal, and failure to do so will typically result in an infection reoccurring.

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Interoperability falls short of turning innovation into transformation. Here’s why.

MedCity News

In healthcare, we tend to mistake “virtual” or “innovative” for “transformative” when, in fact, building shiny new digital tools often forces us to deprioritize strengthening healthcare’s biggest building blocks.

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EEG Caps for Brain Organoids

Medgadget

Researchers at Johns Hopkins University have created tiny EEG caps for brain organoids. The team was inspired by full size EEG caps that are used to measure brain activity in human patients. Previously, the Hopkins researchers were forced to use flat electrode arrays that were originally designed to take recordings from cell monolayers, but applying a flat surface to a round organoid only results in measurements from a handful of cells that make full contact.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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10 highest-paid CEOs of health insurance companies

MedCity News

Notably, in the list, the so-called disruptors of the insurance industry are the ones whose CEOs appear to be winning financially even though their stock performance has left much to be desired.

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UNICEF signs first ever malaria vaccine supply contract with GSK

European Pharmaceutical Review

UNICEF has awarded GSK the first ever contract for the supply of a malaria vaccine. Under the $170 million (€167.4 million) contract, GSK will deliver 18 million doses of RTS,S/AS01 (RTS,S) over the next three years. According to UNICEF, nearly half a million children died from malaria in Africa in 2020, at a rate of one child death per minute, so the supply contact could save thousands of lives every year.

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Gilead Sciences’ long-acting HIV drug gets European Commission approval

MedCity News

European marketing authorization of the Gilead Sciences drug, Sunlenca, provides a twice-yearly treatment option for HIV patients whose virus has become resistant to multiple therapies. An FDA decision for drug is expected in December.

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New study use musical tests for early detection of cognitive decline

PharmaTimes

Researchers at Tel Aviv University used a portable brain activity-measuring device to detect cognitive decline in older people

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Towards ‘smart’ vaccine development and manufacturing

European Pharmaceutical Review

THE GLOBAL outbreak of the COVID-19 pandemic triggered an urgent need to protect people’s lives and livelihoods and the healthcare community recognised quite early that vaccines were the best solution to this crisis. However, the biopharma industries realised that traditional vaccine development and manufacturing techniques, which take around five to 10 years for initial development to large-scale distribution, 1 were inadequate to meet the growing demand for COVID-19 vaccines.

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Patents, pandemics and pricing: a peek at the top drug from every big pharma

PharmaVoice

A look at how the biggest pharma companies in the world and their top-selling drugs fared in the first half of the year.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Pfizer, BioNTech seek FDA authorization for omicron-adjusted Covid-19 boosters

MedCity News

Pfizer and BioNTech have completed their filing seeking FDA emergency use authorization of their omicron-adapted Covid-19 booster shot. Production of this bivalent vaccine has already begun, enabling the companies to begin distribution as soon as the FDA authorizes the shot.

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What is the Best Way to Define Your Weakness in a Job Interview?

MedReps

Among the many questions asked in a job interview is the one dreaded question about your weaknesses. We’ve all heard it and knew it was coming. The interviewers assume that no one is perfect, not even the ideal candidate, so they feel the need to inquire about what you feel is your weakness. How should you respond when you’re asked about your weakness in an interview?

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Anthem BCBS in Virginia selects Confidant Health for mental health/substance use support

MedCity News

Members of the payer struggling with opioid use disorder can access a full suite of health services offered by Confidant Health that include medication management, therapy, counseling and group support.

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Important Dilling’s Rule Dose Calculator 2022

Teachntest

Dilling’s Rule Dose Calculator Dilling’s Rule Dose Calculator Child Dose Calculation *Dilling’s Rule (For calculating doses for age 4 to 20 years) This formula is as follows: Child’s dose = Age in years /20 x Adult dose Calculate In javascipt Enter Adult Dose (mg): Enter Age of the Child (yrs): Child Dose (mg) is: Note: […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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How healthcare organizations can find a balance between personalization, data privacy and HIPAA compliance

MedCity News

Here are three considerations for ways HIPAA can navigate the intersection between personalization and data privacy while meeting regulatory requirements.

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Important Young’s Rule Dose Calculator 2022

Teachntest

Young’s Rule Dose Calculator Young’s Rule Dose Calculator Child Dose Calculation Young’s Rule (For children under 12 years of age) Young’s Rule is a formula for calculating paediatric medication dosage based on the patient’s age and the known adult dose. Young’s Rule is defined as the patient’s age divided by the age added to twelve, […].

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How to remain compliant – and keep patients happy – amid implementation of the No Surprises Act

MedCity News

A revenue cycle management operation that utilizes the right automation and patient collections solutions helps providers to better pinpoint what a patient will have to pay for their care, creating the transparency that is required to remain compliant with the No Surprises Act.

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Jazz Pharmaceuticals’ epilepsy drug advances into phase 3 trial

PharmaTimes

Epidiolex may ease symptoms associated with Doose syndrome, a rarer type of childhood-onset epilepsy

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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3 ways to retain talent in today’s healthcare climate

MedCity News

Now is the time for healthcare organizations to embrace many of the ‘future of work’ concepts already in place in other industries.

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Flipping the script to disrupt, redefine and accelerate the patient care journey

PharmaVoice

A new, digitally innovative care model empowers patients and expedites their access to treatment.

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API nitrosamines: method sensitivity issues

European Pharmaceutical Review

HARDLY A DAY goes by without mention of a newly emerging active pharmaceutical ingredient (API) nitrosamine, eg, nitrosamine propranolol. 1 This has led to a great deal of pre-competitive data sharing. For instance, Lhasa initiated a Nitrites in Excipients database to facilitate risk assessment of drug products, which was recently published. 2,3 The database categorises excipients thus: 1) excipients show varying nitrite contents with pronounced batch-to-batch variance, 2) the nitrite impact is

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Digital health firm Akili raises $163m in Nasdaq listing

pharmaphorum

Akili has started trading publicly today, raising $163 million as a result of its merger with a blank cheque company, saying the cash injection will help fund further development of its video-game based digital therapeutics (DTx). The company made its debut on the Nasdaq on Friday under the AKLI ticker with a starting share price of $9.65, and made swift gains, more than doubling to $20-plus in trading today having spiked as high as $36.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Clarify Health Expands Strategic Partnership with Datavant to Connect Real-World Data and First-Party Data Across Life Sciences

Clarify Health

Datavant’s privacy-preserving tokenization and high-accuracy matching technologies will be used to link real-world data with first-party datasets like clinical trial data and specialty pharmacy data Clarify Health’s Atlas analytics platform has mapped payer-complete, real-world patient journeys that will be linked to first-party datasets across life sciences to deliver novel patient journey, provider, and payer insights SAN FRANCISCO, Aug. 22, 2022 (GLOBE NEWSWIRE) — Clarify Health , a le

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Business Spend management for Today and Tomorrow: Creating a Scalable Foundation for Growth

PharmExec

Tue, Aug 23, 2022 1:00 PM EDT Hear how Werewolf Therapeutics successfully transformed its spend management processes by driving efficiencies; increasing savings; and implementing efficient, compliant systems on a scalable foundation for growth. How do procurement and finance leaders at biopharma companies plan for a future that has unknowns and uncertainty?

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Will Pharma turn to tech for faster market access reporting?

Clarify Health

Market Access Interview. Interviewer: Rachael Hellman. Interviewee: Colin Taggart. While pharma companies are continuously innovating internal processes and implementing novel technologies to gain efficiencies across R&D and commercial, one function has lagged the others: market access reporting. It’s a process that I believe is ripe for innovation, but I wanted to hear from an expert with hands-on market access pharma reporting experience about its ripe for innovation.

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Porton raises funds for gene and cell therapy CDMO platforms expansion

Pharmaceutical Technology

Porton Advanced Solutions has raised $80m in a Series B funding round to expand its end-to-end gene and cell therapy (GCT) contract development and manufacturing organisation (CDMO) platforms. Merchant Health, a healthcare private equity (PE) fund of China Merchants Groups, led the financing round together with its sister fund China Merchants Capital and China Merchants Securities Investments.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Clarify Health Expands Strategic Partnership with Datavant to Connect Real-World Data and First-Party Data Across Life Sciences

Clarify Health

Datavant’s privacy-preserving tokenization and high-accuracy matching technologies will be used to link real-world data with first-party datasets like clinical trial data and specialty pharmacy data. Clarify Health’s Atlas analytics platform has mapped payer-complete, real-world patient journeys that will be linked to first-party datasets across life sciences to deliver novel patient journey, provider, and payer insights.

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How to Use Marketing Automation to Enhance the Patient Journey

LEVO Health

As the healthcare landscape evolves, patients become increasingly proactive in seeking information and taking charge of their health. This shift has had a profound impact on the success of various healthcare marketing strategies. As a result, one of the most powerful, innovative tools is marketing automation. . Marketing automation is technology that manages engagement across various channels and automates marketing and sales processes to: Provide educational information.

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Compliance to convenience: understanding the latest innovations in capsule formulation

Pharmaceutical Technology

When it comes to pharmaceutical, nutritional or cosmeceutical dosing, some of the most crucial parameters are safety, product effectiveness and patient adherence. The right formulation can have a huge impact on whether the customer continues taking their capsules, as well as whether the ingredients act as intended. Today, innovations in the capsule formulation space are creating new possibilities for how capsules look, feel and act, with huge benefits for customers.

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EU advisors back lower monkeypox jab dose to stretch supplies

pharmaphorum

The EMA’s Emergency Task Force (ETF) has recommended that EU member states can use a different regimen for Bavarian Nordic’s monkeypox vaccine Imvanex/Jynneos that uses a smaller dose, to eke out limited supplies of the shot. The recommendation comes after a review of a clinical trial which found that delivering a smaller dose intradermally – just below the top layer of the skin – is as effective as giving the standard dose subcutaneously as recommended on the monkeypox vaccine’

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.